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The overlap of Atg18p and Vac7p sites at a position close to the Fab1p-binding site is consistent with competitive regulation of Fab1p by its positive and negative regulators.
Our algorithm overcomes these issues by considering overlaps of dependency graphs originating from different regulatory nodes, thus taking into account competitive regulation of target genes.
One possible scenario may be the competitive regulation of opposing MAP kinase phosphatases (MKPs).
Mechanisms responsible for the competitive regulation of ERK and JNK are not clear, and warrant future studies.
Additionally, it is unknown whether and how interneurons take part in such competitive regulation of synaptic connectivity.
Taken together, these results lead us to propose the following model for bidirectional competitive regulation of GABAergic synapses by glutamate signaling.
Similar(53)
Indeed, one federal court of appeals seems to have given up entirely, explaining, in the context of lending its imprimatur to Oklahoma's nakedly anti-competitive regulation of casket sales that "while baseball may be the national pastime of the citizenry, dishing out special economic benefits to certain in-state industries remains the favored pastime of state and local governments".
Of the two types of TCPs, class I is associated with growth activation and class II with growth arrest; and the DNA binding motifs identified for each class overlap partially, raising the possibility of competitive regulation via shared promoter elements [ 27].
The existence of such competitive regulation in the apple ECM warrants future study.
Even though cases of explicit competitive regulation are mentioned in the literature [ 10], the current study is the first to inquire on the differences in the dynamical behavior between the two scenarios.
Both these regulators have a significant individual influence on the expression of the modules, but they also have a highly significant negative cross-term indicating the competitive regulation.
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