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Interestingly, competitive modification between O-GlcNAcylation and phosphorylation on Ser/Thr residues of substrate proteins may be closely related with functional switch.
The well-known example of negative crosstalk between PTMs is the competitive modification of different modifiers on a single residue.
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Here, we link host susceptibility to viral infection to a network encompassing sulfur metabolism, tRNA modification, competitive binding, and programmed ribosomal frameshifting (PRF).
It is important to establish separate functions and to gain further insight into the underlying mechanisms that include competitive exclusion and modification of colonic microflora.
As such, it is plausible that through modification of competitive interactions within and between niches rather than creation of novel niches, resident niche occupation could potentially promote or inhibit diversification of an invading lineage.
This latter study revealed that parasitized hosts are weaker competitors, thus unveiling indirect costs of infection through the modification of competitive ability.
Taken together, these observations suggest that the combined network score prioritizes TFs that regulate functional gene modules and are also highly regulated themselves at the protein level, either by nuclear translocation, chromatin modification partners, competitive binding, or signaling pathways.
Do not use this modification during competitive play.
Our future studies will evaluate morphometric and cephalometric modifications after competitive swimming activities, using lateral head films and/or cone beam computed tomography.
Phage clones binding specifically BDE-47 were selected by competitive elution with minor modifications to the previously described method.
Acetylation of H4K16 impeded in vitro ribosylation at this residue, indicating a competitive relationship between these modifications [ 44].
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