Sentence examples similar to competitive compound from inspiring English sources

We found that these ATP competitive compounds are irreversible inhibitors of Jak3 enzyme activity in vitro.

For D-serine competitive compounds, kinetic equations (3) and (4) (see the Experimental section) were used to derive an inhibitory constant (Ki), as reported in Table 1.

Furthermore, the potency, affinity and mechanism of action of a new non ATP-competitive compound were established.

The substrate-competitive compound BIX-01294 was identified as a selective G9a inhibitor by high-throughput screening.

This insight spurred the development of additional Bcr-Abl inhibitors such as the ATP-competitive compound dasatinib (DST).

The myristate pocket was targeted by the non-ATP-competitive compound GNF-2/GNF-5 that led to inhibition of pan-TKI resistant Bcr-Abl variant T315I in a mouse model in combination with nilotinib (Zhang et al., 2010).

Both ATP-competitive and ATP non-competitive compounds were simulated.

Both ATP-competitive and ATP non-competitive compounds had qualitatively indistinguishable results.

Examples of ATP-competitive compounds that more broadly affect HKs have also been reported.

AZD5363, GDC-0068, GSK2141795, and GSK690693 are ATP-competitive compounds that have shown antitumor activity in preclinical models and recently entered phase I trials.

Theoretically, the ATP-competitive compounds work as kinase inhibitors by a reversible mechanism, relying on noncovalent interactions with the ATP pocket of the kinase.