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How might researchers go about reviewing the evidence when they are faced with multiple or indeed competing interventions addressing the same problem?
We do not question the value of the randomized design of 'treatment' trials for comparing competing interventions (treatments), but we have serious concerns about the use of randomization in the evaluation of a diagnostic test, such as CT.
The funding of the intervention is vital and given the scarce resources and competing interventions (malaria and non-malaria related) countries may recognise the advantages of introducing IPTi but struggle to secure the funds.
Healthcare decision-making requires comparisons of all relevant competing interventions.
For cost-effectiveness evaluations of competing interventions that aim to improve survival, differences in expected survival between the competing interventions are of interest.
3 Sound decision making requires comparisons of all available, relevant competing interventions.
This approach facilitates [ 13] the comparison of cost-effectiveness findings across competing interventions [ 14].
They allow estimation of longer-term clinical outcomes and costs and help decision makers make informed choices between competing interventions.
Randomization attenuates bias arising from treatment selection, thereby providing the highest quality data for comparing competing interventions.
The present study demonstrates the use of risk-benefit analysis to perform indirect comparisons of multiple competing interventions.
New methods of evaluating the relative effectiveness of competing interventions may provide unique opportunities for comparative effectiveness research.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com