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Although both PUMA and tBID have been considered equally competent to induce both steps of BAX activation in certain cell-free assays (Kim et al, 2009), our results are more consistent with a model where PUMA and tBID cooperate to induce BAX activation.
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In this study we showed that cells undergoing primary (parental) replicative, oncogene- and drug-induced senescence secrete factors competent to induce enhanced ROS production, DNA damage response and, indeed, paracrine cellular senescence in normal human fibroblasts.
The mesenchyme, however, was competent to induce a gland in non-gland tissue from E11.5, indicating that for a period both tissues have the instructive capacity to induce a gland.
This study was designed to investigate whether signals from injured rat skeletal muscle were competent to induce a program of myogenic differentiation in expanded cultures of rat bone-marrow-derived mesenchymal stem cells (MSC).
This present study was designed to use conditioned medium to investigate whether signals from pathological condition of ALS were competent to induce a program of neurogenic differentiation in expanded cultures of hMSCs.
We observed that even with G93A seeds that are highly competent to induce aggregation in G93A, the G93A-S32 substrate was resistant to fibrillation, displaying altered fibrillation kinetics with an increased lag-phase (~3 fold, Fig. 2B), reduced elongation rate (~4 fold, Fig. 2C), and lower ThT signal at endpoint (~5 fold) (Fig. 2A).
Nonetheless, Chk1D469G is competent to induce a checkpoint dependent cell cycle delay.
These observations demonstrate that the recombinant virus is competent to induce antibody responses in the mucosal tissues.
While incapable of being ubiquitinated itself, we demonstrate that lysine-deficient TRAF6 remains competent to induce ubiquitination of IKKγ/NEMO.
He we have shown that GP42 vector is competent to induce local immunity at the mucosal surfaces as well as systemic immunity.
These data indicate that GP42-H1 infectiousous in cell lines and is competent to induce HA protein expression on cell surfaces.
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