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Altogether, these data provide the first genetic evidence that Bmp and Fgf signaling are essential for hepatic specification, and suggest that endodermal cells remain competent to differentiate into hepatocytes for longer than anticipated.
These ENCs may thus not be fully competent to differentiate under these culture conditions.
Nevertheless, including the genes undetectable by MIAMI, many hypomethylated sequences in astrocytes are already demethylated in E14.5 NPCs, which are competent to differentiate into astrocytes.
Coupled with the reduced capability of cells to differentiate to primitive streak-like intermediates, these data suggest that FGF signalling in the epiblast functions to make primitive ectoderm competent to differentiate.
When DLC2−/− and DLC2+/+ cells were induced by standard adipocyte differentiation induction medium, both DLC2−/− and DLC2+/+ cells were competent to differentiate into adipocytes and did not significantly differ in lipid production quantitatively (Figure 5).
Recent studies point to the existence of multiple epidermal stem cell pools that are competent to differentiate along all the epidermal lineages, but are normally lineage-restricted as a result of specific environmental cues.
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Furthermore, CD8+ T cells primed by the antigen-presenting liver parenchyma cells fail to differentiate into competent effectors.
"He looks competent to me".
Is Mr. Holmes competent to stand trial?
The writing ranges from competent to incomprehensible.
I am not competent to do so".
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com