Furthermore, EDC could modify the RGD motifs that are present, but sterically hindered from integrin binding, in the latent form in collagen but become active on denaturation (in gelatin) and become competent to bind some of the fibronectin-binding integrins [51].
In the nucleus, AhR and AhR nuclear translocator (Arnt) dimerize to form the AhR Arnt heterodimer, which is competent to bind XRE in the promoter of specific genes such as CYP1A1.
The openings are found in the active conformation, in which opsin is competent to bind and activate the G protein transducin.
This coincides with the previous observation that S62A-Bcl-xL mutant was more competent to bind Bax than the S62D mutant using co-immunoprecipitation experiments.
In the present study, module 1 was assembled independently and was found to be competent to bind base-CP, however in the crowded milieu of the cytosol, other assembly pathways may exist in parallel.
Nevertheless, ppGpp binding indicates that the metazoan LIC is indeed competent to bind nucleotide and also raised questions of its nucleotide specificity, especially since we did not detect bound GTP, which is present in millimolar concentrations in bacteria (Buckstein et al., 2008).
While we found that there are substantial amounts of kermit2 in Xenopus embryos our GST pull downs and coimmunoprecipitations suggest that only a small fraction of kermit2 in the embryo is competent to bind to endogenous α5β1 integrin.
Our initial experiments to test the prediction have shown Sho RGG box peptide is competent to bind RNA but further work is required to characterize the interaction.
Previous studies have shown that the truncated versions of Smo lacking either CRD or the C-terminal domain remain competent to bind cyclopamine and other cyclopamine-competitive ligands, consistent with these molecules interacting with the 7TM segment (Chen et al., 2002a; Wang et al., 2013).
