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Thus, midbrain neuroepithelium may be more competent to activate Shh expression.
Taken together, the data suggest that Smo can adopt multiple conformations that allow ciliary trafficking, but only a subset of these are competent to activate the Hh cascade.
While all cells of the model meristem are in principal able to express WUS, we added a spatial parameter which makes cells that reside closer to the meristem tip more competent to activate WUS expression (Fig. 1B).
LNCaP cells, on the other hand, were competent to activate NF-κB in response to RSV infection.
This truncated form has been shown to be transcriptionally competent to activate a subset of known PGC-1α target genes in brown adipocyte tissue (Zhang et al., 2009).
To determine which, if any, adult tissues are competent to activate an islet β cell program, we performed an in vivo screen by expressing three β cell "reprogramming factors" in a wide spectrum of tissues.
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To assess whether the lack of an ex vivo response in HuD+/+ mice was due to ineffective immunization, splenocytes stimulated in vitro with p321 were assayed and found to be competent to generate activated HuD p321-specific CD8+ T cells (Fig 3d).
As the mouse ages, this process creates increasingly complex patterns of hair growth with each domain consisting of a telogen competent to be activated, a propagating anagen wave, a catagen, and a refractive telogen [ 3, 25].
When an immune response is triggered, dendritic cells (DCs) and macrophages mature into fully competent antigen-presenting cells able to activate T cells [19].
We hypothesized that the release of mitochondria cellular organelles that are thought to have originated as symbiotic bacteria could serve to activate immune-competent cells.
Interestingly, although the induction of Noxa in the p65-reconstituted cells was completely ablated by DN-p73β, the ectopic expression of a transactivation-competent version of p73β failed to activate expression of Noxa in the p65-null cells.
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