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The aptamer in its ligand-binding competent structure represents one structural conformation of the switch while an alternative fold that disrupts the binding-competent structure forms the other conformation.
More energy is required for ergosterol synthesis than for cholesterol, and in addition cholesterol has been shown to be the most functionally competent structure in artificial membrane systems [31].
Since IZUMO1 has a simple structure compared to other fusion proteins [6] with no "fusogenic" peptide or "SNARE" like structure in it, we entertained the possibility that IZUMO1 is one of the components that form a fusion competent structure on sperm.
In the subclass IB RcFPR:NADP+ complex, the nicotinamide hydride donor protrudes towards the solvent, far from producing a competent structure for hydride transfer [ 13].
Ccm1p would perfectly fit this scenario as a factor that assists the full-length bI4 intron in acquiring the competent structure towards a catalytic form.
Furthermore, distinct spatial interactions of the LCR in fetal and adult stages were uncovered by another study based only in 3C assay in which HBD sequence was proposed to be enrolled in the maintenance of a transcriptionally competent structure at the adult stage (Beauchemin and Trudel 2009).
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4- Rationalization of the institutional framework: To more competent structures with the necessary technical, human and financial technical abilities.
Fibril assembly is initiated by a critical nucleation step in which multiple Tau molecules join into a propagation-competent structure.
The breast lobular component expands and differentiates with pregnancy and lactation transforming the relatively rudimentary gland into an alveolar rich lactation-competent structure [ 44].
We next investigated whether insoluble PrD- and Sup35-polyQ protein aggregates formed in vivo are seeding-competent structures that can convert endogenous Sup35 protein from the soluble to the insoluble state.
To investigate whether the insoluble PrD-polyQ protein aggregates are seeding-competent structures that can stimulate the amyloidogenesis of other soluble Q/N-rich proteins, an in vitro seeding assay was established (Fig. 1D).
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