Sentence examples for competent seed from inspiring English sources

Combined with our current results, the breast cancer cells which expressed both TGF-β and PTHrP can be the competent seed that has the capacity to metastasize to bone.

Based on this hypothesis, stronger seeds may obtain resources more efficiently than less-competent seeds (which will ultimately starve).

The propagation of Tau pathology in Alzheimer's disease (AD) is thought to proceed through templated conversion of Tau protein into fibrils and cell-to-cell transfer of elongation-competent seeds.

In conclusion, long polyQ sequences are powerful molecular tools that allow the efficient production of seeding-competent amyloid structures.

In GT17 cells, endogenous Sup35 protein is soluble; however, it might covert into insoluble aggregates when seeding-competent PrD- or Sup35-polyQ proteins are expressed.

Previous studies have demonstrated that self-assembly of seeding-competent Sup35 aggregates in vitro critically depends on the activity of the molecular chaperone Hsp104 [35].

Thus, it seems reasonable to speculate that Hsp104 maintains Sup35 aggregates in [PSI+] cells not only by severing existing aggregates but also by promoting the formation of new seeding-competent insoluble structures [35], [52], [53].

We found that PrD and Sup35 fusions with long, pathogenic polyQ tracts (≥54 glutamines) efficiently self-assemble into seeding-competent, SDS-stable protein aggregates, while fusions with short, non-pathogenic polyQ tracts (19 glutamines) or proteins without a polyQ tag do not.

Sonication was employed to break the Htt-ex1 amyloid fibers down into small aggregates and globular seed species that were competent for growth.

The authors tested whether CE culture chondrocytes were advantageous for producing mechanically competent cartilage matrix when three-dimensionally seeded in dense collagen gels.

To investigate whether the insoluble PrD-polyQ protein aggregates are seeding-competent structures that can stimulate the amyloidogenesis of other soluble Q/N-rich proteins, an in vitro seeding assay was established (Fig. 1D).