Sentence examples for competent orientation from inspiring English sources

Therefore, the flavonoids can scuttle binding of the fatty acid or prevent it from binding in a catalytically competent orientation.

This suggests that UDP-Ara4N is bound in a physiologically relevant, catalytically competent orientation in the structure.

Overall, we conclude that the inhibitor acts by preventing the binding of NADPH and disrupting the catalytically competent orientation of the catalytic triad.

(26) These Uaas could readily rotate the α-carboxyl and α-amino groups along the Cα-Cβ bond to achieve a catalytically competent orientation.

Upon inversion of the hTERT cDNA to a transcriptionally competent orientation via the action of Cre recombinase, cells acquired telomerase activity, telomere DNA was replenished, and the population was immortalized.

(26) The main chain atoms of Pyl sit in a catalytically competent orientation consistent with the expected in-line nucleophilic attack of an oxygen atom from the α-carboxyl group on the α-phosphate atom of AMP-PNP By contrast, in MmOmeRS, the α-amino group of Ome sits proximal to the α-phosphate of AMP-PNP through an intervening network of water-mediated interactions.

This suggests that loss of the hydrogen bond between Thr1700 and Ser1655 in T1700A drastically changes the conformational space sampled by the Hγ diminishing the number of orientations competent for phosphate recognition.

The pEPG expression plasmid thus obtained was used to transform E. coli TOP10 competent cells, and the correct DNA orientation selected by digestion with the restriction enzyme Sma I (Takara).

This orientation facilitates a near catalytically competent end-synapsis configuration that positions the 3′ primer strand in the active site of the adjacent polymerase to permit extension to occur in trans, discussed below.

The construct ilvB-pAZI94066) thad had the target gene in the antisense orientation was transformed into M. tuberculosis competent cells by electroporation.

Thus we can estimate that most of the proteins (>80%) was incorporated in the right orientation (i.e. inside-out topology) competent for ATP hydrolysis when reconstituted from a fully solubilized mixture of lipid/proteins/detergent.