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36 However, phosphorylation at other sites and competent interaction with coactivators also play a role in determining its activity.
Therefore, a relatively large conformational rearrangement should take place in this region to achieve a catalytically competent interaction.
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Altogether the results indicate that neutral membranes are able to interact with Penetratin which confirms that the phosphate negatively charged groups exposed on the external leaflet of plasma membrane are competent for interaction with the basic peptide.
If the face evolved in part as a device to optimize transmission of facial expressions then the primate brain probably co-evolved as an efficient decoder of these signals: Competent social interaction implies a fast, on-line identification of facial expressions to enable adaptive actions.
This suggests that the scanning state should be competent for interaction with the SRP receptor, potentially permitting targeting while the TMD is still inside the tunnel.
Mainly negative symptoms are considered to better reflect social dysfunction as the nature and chronicity of which, seem to interfere in competent social interaction.
Thus, displacement of the Ubl domain by phosphoubiquitin binding may lead to exposure of a surface competent for interaction with ubiquitin.
However, HER2 and HER3 are not able to stimulate cell signalling as monomers as HER2 does not possess an ectodomain competent for interaction with any ligand, whereas HER3 lacks the kinase complex [ 7].
The host chaperone complex associates with DP and HP and is required to establish and maintain the polymerase in a conformation competent for ε interaction in a dynamic process driven by ATP hydrolysis.
The likely role of Thr171 phosphorylation is to orient these five residues so their side-chains are in a binding competent mode for interaction with an unidentified RNA processing factor.
The activation loop in mTOR is similarly held in a catalytically competent conformation via interactions with a highly conserved and integral ∼35 residue FATC domain, which is stabilized through packing interactions with a ∼40 residue insertion in the C-lobe termed the LBE (Yang et al., 2013).
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CEO of Professional Science Editing for Scientists @ prosciediting.com