The process of using previously catalytically competent domains as scaffolds is plausible from an evolutionary perspective as enzymes have evolved to bind their substrates.
Perhaps the virion cholesterol is important for the organization of influenza virus HA trimers into fusion-competent domains, and perhaps also the depletion of cholesterol inhibits virus infectivity due to inefficient fusion [ 52].
P1 promoter controls the TAp73 transcripts containing exons 1 3 that encode N-terminal sequences with transactivatory activity (TA), and ΔEx2, ΔEx2 3 and ΔN' transcripts collectively designate ΔTAp73 that lack a fully competent TA domain (Stiewe et al, 2002a, 2002b).
The development of safer vectors incorporating enhancer-less regulatory elements that are capable of establishing and maintaining a transcriptionally competent chromatin domain, and which give rise to reproducible and stable transgene expression irrespective of tissue type or site of integration, is therefore of considerable interest.
However, Sanders et al. [ 80] recently demonstrated that different species of aggregated tau templated themselves with high fidelity through serial passages of HEK cell lines that stably expressed the aggregation-competent repeat domain of this protein.
People are usually more competent in one domain while being less competent in others (e.g., accounting, baseball, chess).
According to our findings, acceptance merely implied that teachers resigned themselves to the fact that they cannot know everything or be competent at every domain, instead of implying that teachers would increase their efforts.
The identification of elements capable of maintaining a transcriptionally competent ("open") chromatin domain resistant to silencing, irrespective of tissue type or integration site, is therefore an important objective in the development of technology giving more efficient transgene expression in mammalian cells, for many important applications.
On average, clients were rated significantly more competent in six domains over the course of time.
The dimerization-competent conformer contains domain II in an exposed, rather than buried environment.
