Sentence examples for competent configuration from inspiring English sources

This may lead to subtle structural changes in the relative orientation of the domains and active site architecture, preventing ABCTP binding in a catalytically competent configuration.

Formation of a catalytically competent configuration seems to be associated with closing of a flexible loop in association with the substrate, which isolates two water molecules at the catalytic centre [ 39].

Through the crystal structure of the GM-CSF extracellular receptor complex, it is thought that a dodecameric structure is formed which results in a signalling competent configuration where the signalling βc intracellular domains are in close proximity [ 28].

This likely reflects that the fact that the key activation event for these enzymes is the binding of regulatory proteins that coerce the kinase domain to close into a catalytically competent configuration.

Like other USP structures (Hu et al, 2005; Avvakumov et al, 2006; Renatus et al, 2006; Köhler et al, 2010; Samara et al, 2010), except USP7 (Hu et al, 2002), the catalytic triad is in a catalytically competent configuration, wherein His 711-ND1 is 3.2 Å away from Cys 311-SG and His 711-ND2 is hydrogen bonding with Asp 898-OD1 (2.7 Å; Fig 1B).

The second property (<30 °C) was unexpected and indicates confined/restricted active site geometry for the enzyme ternary complex that, correspondingly, has become impaired in its ability to sample the protein landscape for catalytically competent configurations.

Perhaps the essential role of HOPS in their experiments is not to tether the two membranes, but rather to stabilize Q-SNARE complexes in a fusion-competent configuration.

ATP turnover is initiated by fluctuations at the consensus NBS which enables transition to a hydrolysis-competent configuration (HES-like) as deduced from the overlapping distance distributions in Figure 2.

The PI(3 P experiments in Figure 5 partially address this question, but as the SNAREs are known to interact with PI(3 P, it may be that PI(3 P also stabilizes the fusion-competent configuration.

That may very well be true, but might not the data herein also support the idea that the action of HOPS is merely to stabilize the Q-SNAREs in a fusion-competent configuration such that they can mediate both tethering and fusion?

Finally, the Smc5/6 complex is required for loading RPA and Rad52 onto stalled replication forks to maintain them in recombination-competent configurations [ 90].