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However, these signaling combinations were temporally re-interpreted: cellular competence to respond to retinoid, WNT, TGF-β, and other signals sharply changed within 24 hr.
Sena, G; Jung, JW; Benfey, PN, A broad competence to respond to SHORT ROOT revealed by tissue-specific ectopic expression., Development (Cambridge, England), vol. 131 no. 12 (June, 2004), pp. 2817-2826, [abs] [abs].
The animal caps gradually lost competence to respond to cardiac fate-inducing signal from anterior endoderm, so that by st. 13 very little cardiac tissue was induced (Fig. 3).
Wg signaling provides mesodermal cells competence to respond to Ras signaling, in part through the requirement of Wg to maintain the expression of different components of the Ras pathway [55].
Stimulation of ESCs with these factors at earlier or later times resulted in little Mixl1 induction, suggesting that the differentiating ESCs passed through 'temporal windows' in which they sequentially gained and lost competence to respond to each growth factor.
Several in vitro and in vivo studies showed that Mstn overexpression prevents proliferation and differentiation of muscle precursors by inducing expression of the cell cycle inhibitor p21CIP/WAF, while endowing muscle progenitors with competence to respond to signals favoring muscle differentiation [32].
Similar(33)
Creating realistic job descriptions for each type of healthcare worker and updating knowledge and competences needed to respond to new health problems.
Initially, Smurfs have been implicated in determining the competence of cells to respond to TGF-β/BMP signaling pathway.
Ontologies are expected to have "competence", the ability to respond to queries that draw from the formal relationships among group members.
These data suggest that all endodermal cells at the 5th somite level possess hepatic competence, the ability to respond to hepatic inducing signals, and demonstrate that Pdx1+ non-hepatic endodermal cells were directly converted into Prox1+ hepatoblasts upon Wnt8a overexpression.
Hepatic competence, or the ability to respond to hepatic-inducing signals, is regulated by a number of transcription factors broadly expressed in the endoderm.
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