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Furthermore, over-expression of btd restores the competence to generate INPs in trx mutant type II neuroblasts.
Each cell line is functionally pluripotent as demonstrated by competence to generate high-contribution chimaeras with germline transmission.
Together, these data strongly suggest that trx mutant type II neuroblasts lost the competence to generate immature INPs.
trx mutant type II neuroblasts gradually adopt a type I neuroblast functional identity, losing the competence to generate intermediate neural progenitors (INPs) and directly generating differentiated cells.
Therefore, the aging induced decline in competence to generate T cells is primarily dependent on status of the progenitor niche cells in the BM and thymus.
Verbal comprehension, long- and short-term memory, and the competence to generate concepts are necessary functions for the integration of Verbal IQ (Sattler 1996; Wechsler 1991).
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Studying how people communicate in novel settings provides a window into the mechanisms supporting the human competence to rapidly generate and understand novel shared symbols, a fundamental property of human communication.
Central to genetic studies for Parvovirus B19 (B19V) is the availability of genomic clones that may possess functional competence and ability to generate infectious virus.
Our results showed that although the competence of LPCs to generate thymic T-lymphopoiesis dynamically declined with increasing age, only when the LPCs reached 22 months of age, was the thymic T-lymphopoisis significantly reduced when compared to that of young LPCs (Fig. 5B).
Instead, the pneumococcal competence pilus is suggested to generate a transient opening in the thick cell wall to give way to incoming DNA.
Therefore, it is of utmost importance to determine whether old niches in the BM and/or thymus can directly affect competence of young LPCs to generate T cells.
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