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Here the phase zero of our action oriented competence system is at stake.
It is also possible that the Rickettsia T4SS is an amalgam of an effector translocation system and a DNA competence system, especially considering the redundancy of several of its components.
To circumvent this possibility, the competence system should be deleted once an optimal attenuated vaccine strain has been generated.
Okinaga T, Xie Z, Niu G, Qi F, Merritt J Examinationn of the hdrRM regulon yields insight into the competence system of Streptococcus mutans.
The competence system is clearly part of the regulation of genetic transformation, with the likely function of providing for gene exchange and eventual evolution.
Further, by identifying candidate transporters through a biochemical approach, we expect to be able to delete components of the natural competence system, therefore confirming their role in this process.
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Successfully predicting the capacity for natural transformation based on gene content alone is problematic due to species-to-species variation in competence systems [68].
The complexity of natural competence systems and diversity of streptococcal competence genes has made in-silico prediction of natural competence difficult [ 95].
Competence systems in Gram-positive bacteria share many structural features with the closely related T4P systems and T2S systems 4, 10, 11 (Table 1).
Transformation, by contrast, is a bacterium-programmed mechanism of HGT that is mediated by natural competence systems encoded in the genomes of many bacteria (Lorenz and Wackernagel 1994; Claverys et al. 2009).
ComX activity is modulated by the inputs from two types of signal pathways, namely the competence-stimulating peptide (CSP) dependent competence regulation system and CSP-independent competence regulation system.
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