Consistent with this explanation, even when rapamycin was added with delay, preservation of competence was detectable [ 10].
Remarkably, preservation of competence was detectable at lower concentrations of rapamycin than those that inhibited either S6 phosphorylation or cellular hypertrophy.
Here we determined whether preservation of competence (PC) correlated with inhibition of S6 phosphorylation and the anti-hypertrophic effect of rapamycin.
How can we explain preservation of mitotic competence by rapamycin?
We found that preservation of proliferative (competence) was the most sensitive marker of mTOR inhibition, easily detectable even at concentrations of rapamycin when inhibition of mTOR was marginal.
Preservation of proliferative potential (competence) correlated with inhibition of S6 phosphorylation by rapamycin.
Preservation of proliferative potential (competence) was measured by an increase in live cell number, when p21 was switched off.
" Vision Department of Women's Health", " Additional benefit for the medical speciality and University Medicine) in view of the synergy effects for the preservation and expansion of competence and excellence (strengths, opportunities), which should develop at all levels.
Given this scenario, the preservation of every-day life competence of aged populations becomes increasingly important.
The complementary pattern (i.e., the preservation of referential abilities with loss of inferential competence) had been reported only in few cases (Heilman et al. 1976; Kremin 1986).
