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In this case, the compensatory solution is the ancestral amino acid [ 10].
In one model, a deleterious mutation arises in a background already harboring a fixed or polymorphic compensatory solution [ 10, 12, 23].
Moreover, it was possible to track at least two independent events resulting in the deleterious COIII-Leu251, but again only in lineages harboring the corresponding compensatory solution.
In the first scenario, a mutation persists in the population at low frequencies while waiting for a compensatory solution to arise de novo by mutation [ 25, 26], or as a polymorphism that may become associated via recombination [ 10].
Similar(53)
Redundancy in the neuromuscular system or malfunctioning of injured 'elements' may often result in motor equivalent compensatory solutions.
Two numerical examples with flexibility preferences in source-stream temperatures are supplied, demonstrating that the proposed strategy can provide definite and feasible compensatory solutions for multi-criteria HEN synthesis problems.
In addition, the functional rescue of each particular mutation may involve distinct compensatory solutions [ 19, 20].
Nevertheless, it is known that more than one compensatory site may exist for any given mutation [ 19] and thus phylogenetically related lineages can hold distinct compensatory solutions.
From these examples, we are presenting a model of co-evolution in which genomes hold potential compensatory solutions for upcoming deleterious events.
For example, the algorithm might find a spurious solution with compensatory copy-number state changes across subclones, which is very unlikely on biological grounds but might serve to opportunistically maximize the total log likelihood.
This can in turn result in compensatory gait changes [49].
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