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Indeed, compensatory redundancy between LIN28A and LIN28B has been observed (Wilbert et al., 2012).
With responsiveness to a similar ligand, it is possible that compensatory redundancy exists between LPAR1 and LPAR2.
Similarly, our approach deliberately aimed to avoid using multiple knockout models on both pragmatic and functional grounds given the compensatory redundancy of cytokine networks and/or the unknown postpartum traits of such models.
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However, it has been progressively realized that the interpretation of the results may be complicated by diverse factors such as differences among various inbred mouse lines, existence of compensatory adaptations, redundancies etc.
Heterodimerization, compensatory crosstalk and redundancy exist in the HER2/EGFR network, which provides a sound scientific rationale for dual inhibition of EGFR and HER2.
This raises the possibility that endothelial cells may have additional compensatory mechanisms, including redundancy in the function of other sirtuins, which could have attenuated the effects of the loss of SIRT6.
Other anti-apoptotic Bcl-2 family members were expressed but not substantively altered at the mRNA level in the Bcl-x-null tumors, suggestive of redundancy without compensatory transcriptional up-regulation.
Notably, only mild alterations in dopaminergic neurotransmission have been observed, but no degeneration of dopaminergic neurons, which might be explained by functional redundancy or compensatory mechanisms [6], [7], [8], [9].
A related problem is the redundancy of compensatory systems in the brain.
This is in agreement with earlier reports on redundancy and compensatory actions of both Dnmts and Tet family proteins in accounting for global effects.
Biologically, redundancy and compensatory mechanisms at other loci can mitigate the effects of a devastating mutation or polymorphism at another locus, thus rendering its effect undetectable.
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