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During the first days at weightlessness, the orientation problems (and SMS) disappear, since the brain develops a new compensatory interpretation of the available sensory data.
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The finding that the effect of the secondary mutations was consistent over a number of such clones would support the interpretation that compensatory mutations did not affect our original results.
Consequently, there may need to be additional interpretation of the compensatory calculations used between countries with different sources for their definitive incidence numbers.
Of course, it should be kept in mind that deletion of a specific gene (in this case the Kcnj9 gene) in KO animals may lead to developmental changes in other systems to compensate for this loss, and these compensatory changes can confound the interpretation of knockout studies.
The Alabama Supreme Court is reviewing a $3.4 billion punitive award, on top of a $90 million compensatory award, in a case about the interpretation of an offshore gas lease.
During this delay, compensatory mechanisms can occur which confound data interpretation [1] [4].
Small recordings of overjet might be the result of compensatory mandibular incisors proclination, resulting in false interpretation of maxillary incisors protrusion.
Although intuitive, this hypothesis remains untested, as the constitutive elimination of RGS proteins typically results in an all-or-nothing impact on GPCR pathways, and compensatory changes during development further confound the interpretation of behavioral changes.
Compensatory adaptations represent a significant caveat to the interpretation of experiments utilizing constitutive knockout mice.
However, RNAi also can have off-target or compensatory effects on the proteome that confound the interpretation of results.
Interpretation of these effects as reflecting compensatory mechanisms is controversial (Maccotta et al. 2007; Vlooswijk et al. 2008; Saling 2009).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com