Sentence examples for compensatory feedback from inspiring English sources
Omipalisib displays broad target specificity and may overcome functional redundancy between PI3K isoforms and compensatory feedback loops in this pathway but on-target-toxicities associated with this class of inhibitors could be limiting23,24,25.
However, expression of CD127 on later thymopoietic stages was higher in HIV-infected individuals compared to results obtained in HIV-negative controls (CD3+DP HIV+ 2.3% HIV- 1.3%; SPCD4+ HIV+ 5.8%, HIV-4.6%), suggesting a maintenance of an IL-7 compensatory feedback in HIV infection.
Increased COX-2 gene expression was seen, possibly due to compensatory feedback.
Thus, stability, as well as the compensatory feedback response, is greater at the population compared to the single-unit level.
The upregulation of CDK6 during PD0332991 treatment might have been a compensatory feedback mechanism to keep up CDK6 signalling.
Combination with diuretics may help counterbalance the salt-retaining effects of diabetes and inhibit compensatory feedback loops.
This observation suggests compensatory or feedback mechanisms are part of a complex interplay between the proteases in vivo.
Clinical trials have shown the limited efficacy of single-agent Akt pathway inhibitors, presumably due to the activation of compensatory signaling feedbacks [ 45].
Following a period of speech practice under conditions of altered auditory feedback, compensatory changes in speech production and perception were examined.
We first used mouse xenograft data and quantitatively described time- and dose-dependent CAF modulation following sunitinib with a systems pharmacology model delineating VEGF-induced VEGFR2 activation, signal transduction, tumor growth, antitumor activity, and feedback compensatory mechanisms.
In the case of Akt(T308) phosphorylation, the levels in HRG-stimulated control and miR-149 expressing cells were similar, however, in the latter cells the fold induction was reduced due to increased basal Akt(T308) phosphorylation, possibly resulting from the compensatory activation of feedback mechanisms.
