Unemployment is at a record high and the economy is in its fourth year of recession, To prevent the recurrence of the recent disturbances, the government plans to soften the impact with what Mr. Ruckauf called "compensatory elements" in its economic package.
Differences in physiology (toxicokinetics, toxicodynamics, nutritional requirements, and other biochemical characteristics), anatomical structure, and behavior can lead to positive or negative findings that may not accurately reflect human responses; however, toxicology study design seeks to overcome these limitations by utilizing compensatory design elements (Creton et al., 2012; Gad, 2007).
Although there is an inherent interest in understanding the evolution of these other regulatory elements, in the absence of effective computational approaches, the prevalence of compensatory mutations within such elements remains unclear.
Synthetic lethal interactions can reflect, for instance, non-essential elements of compensatory pathways that converge on the same essential endpoint function.
Jung believed that dreams were instead compensatory, that they balanced whatever elements of character were underrepresented in the way people live their lives.
The maintenance of testis expression in view of the loss of previously identified testis regulatory elements indicates that compensatory evolution has occurred in their β2 cis-regulation.
The primary mechanism linking inhibition of hepatic sterol synthesis to reductions in LDL-C involves compensatory upregulation of sterol regulatory element-binding protein-2 (SREBP2 -dependent gene tranSREBP2 -dependentonse to reduced intracellular cholesterol levels [ 29].
Differences in the frequencies of location-specific motifs among species are often likely to represent compensatory substitutions within cis-regulatory elements throughout the genome, driven by a change in the affinity of the corresponding transcription factor (fig. 1).
In the T3 lines, some compensatory changes were in genes or elements with functions either outside both DNA metabolism and virion components or with unknown functions (Table 1).
