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Dosage compensation is thought to have evolved to compensate for this degradation (Ohno 1967).
Details of settlement were not announced, but the compensation is thought to be more than $5.6 million, or almost $94,000 each, according to the Irish broadcaster, RTE.
The registration statement says Green received $400,000 in salary but no further stock award in 2018; it doesn't mention Zimmer for technical reasons, but his compensation is thought to be the same for 2018.
Dosage compensation is thought to evolve in concert with the formation of heteromorphic sex chromosomes (Charlesworth 1996; Mank 2013).
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Due to these findings, the physiological mechanisms behind dosage compensations are thought to be acting primarily on the protein level.
This second approach is a better reflection of the biology of dosage compensation, which is thought to arise primarily to readjust the Z/X to autosome expression ratio in the heterogametic sex.
In both clinical and experimental PD, the brain has a remarkable capacity for compensation, and this is thought to account for the fact that overt motor symptoms may not be apparent until around 80% of striatal DA and 60% of SNc DAergic perikarya are lost (Bassilana et al., 2005; Bezard et al., 2001, 2003; Castaneda et al., 1990; Song and Haber, 2000).
Dosage compensation for sex-chromosomes is thought to have evolved in order to prevent debilitating gene disbalance, as dramatically exemplified with various human diseases due to aneuploidy of sex-chromosomes, autosomes or portions of chromosomes [17], [18].
If dosage compensation does occur, it is thought to be through a mechanism that is independent of the DCC (Gupta et al. 2006).
Whilst the compensation (or protection) index is thought to reflect the generosity and accessibility of benefit programmes for the workforce in case of disability, the integration index measures public labour market programs that aim to re-integrate groups of individuals in case of disability.
It is thought that none of them will receive a pay-off or compensation package.
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