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We hypothesized that MrD was involved in the pain modulation in headache, and that the decreased functional connectivity of MrD would generate the pain and might be the cause of migraine, while the increased functional connectivity of MrD would be complementary for pain and might compensate the dysfunction of MrD neuromodulation.
It remained unclear whether the reduction of Comt and the upregulation of the DA receptors were sufficient to compensate the dysfunction in DA signaling.
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The second-order pain complementary network is mainly revealed in the right precentral gyrus and right insula, which could compensate for the dysfunction of MrD neuromodulation and prevent migraine chronicization.
The results also suggest that functional changes related to some symptoms dimensions occur to compensate for the dysfunction associated with other symptoms.
A brain's ability to compensate for the dysfunction and loss of neurons, occurring over a long period of time, results in late clinical manifestation of symptoms of AD and other dementias.
Note that this test is performed with eyes open, but it seems that this degree of difficulty exceeds the previously proven ability to compensate for the dysfunction in the proprioception by visual input, when the cleaners have pain at two spinal sites.
To address whether the observed cardiac dysfunction caused by shox2 deficiency could depend on isl1 function, we examined the ability of isl1 to compensate the morpholino-mediated loss of shox2 function by transient rescue experiments.
Mitochondria dysfunction induces the retrograde response that activates genes compensating this dysfunction [ 42].
We therefore sought evidence that the ipsilateral M1 can compensate for dysfunction of the contralateral M1.
It is likely that other genes within or related to the HOX cascade partially compensate for dysfunction of the mutated HOXA1 gene, leading to variable symptoms in affected individuals.
The increased expression of nuclear encoded genes in response to altered mitochondrial bioenergetic state, compensating the effects of mitochondrial dysfunction or stress, is known as retrograde signalling (Fig. 2).
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CEO of Professional Science Editing for Scientists @ prosciediting.com