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In order to gain a clearer insight into the underlying mechanism for this differential sensitivity, we interrogated differences in other DNA repair enzymes based on the hypothesis that the activity of these complementary pathways may compensate for the consequence of PARP inhibition.
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Our approach is to fulfill the first requirement and to compensate for the consequences of the second one.
Moreover, the coordination deficits in pcd are consistent with a failure to predict and compensate for the consequences of movement across the body.
Consequently, adaptive growth of pre-existing collateral arterioles bypassing an occluded conductance artery appears to be a prerequisite to compensate for the consequences of arteriosclerosis.
In addition, increasing muscular mass may also compensate for the consequences of carapace fortification or altered hydrodynamics resulting from a changed carapace morphology.
It is commonly accepted that allergic reactions may have the same or even worse manifestations in the elderly than in younger individuals; however, due to the aging decline in function of various systems, such as the cardiovascular system, older patients may not be able to compensate for the consequences of an allergic reaction.
Finally, the large, oscillatory nose and tail movements observed in pcd were not just random, but were successfully modeled as a failure to predict and compensate for the passive consequences of forward motion of the hind limbs.
This explains why small island states think it is so important to set up an international mechanism for loss and damage, to compensate for the irremediable consequences of global warming.
Both state-owned and private Russian industrial enterprises have begun searching for potential Chinese partners that could compensate for the negative consequences of breaking ties with Europe.
Protocols for telephone triage include not only questions about possible causes and the consequences of the symptom presented but also questions to compensate for the lack of visual information about a patient's clinical condition.
It is possible that other RAB proteins compensate for the loss of RAB18 in synaptic vesicle recycling, but not for the major neuropathological consequence of widespread cytoskeletal disorganisation in neurons.
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