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We therefore sought evidence that the ipsilateral M1 can compensate for dysfunction of the contralateral M1.
This means that some mechanisms to compensate for dysfunction of a single protein might exist, indicating that inhibiting a single target would be therapeutically insufficient [1].
Similarly, increased activity of the cerebellum during movements has been observed frequently in Parkinson's disease perhaps to compensate for dysfunction of dopamine-dependent circuits (Rascol et al., 1997; Yu et al., 2007; Wu et al., 2010 b ).
It is likely that other genes within or related to the HOX cascade partially compensate for dysfunction of the mutated HOXA1 gene, leading to variable symptoms in affected individuals.
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Moreover, we identify novel AMA RON pairs that reflect the considerable genetic and molecular plasticity at the disposal of Apicomplexa to compensate for dysfunction in the core invasion machinery.
This study highlights considerable genetic and molecular plasticity of the T. gondii genome to compensate for dysfunction in the core MJ machinery.
By contrast, a different group of calcium channels, the R-type, influence neuromuscular transmission and can compensate for dysfunctioning P/Q channels [27].
The second-order pain complementary network is mainly revealed in the right precentral gyrus and right insula, which could compensate for the dysfunction of MrD neuromodulation and prevent migraine chronicization.
We therefore propose that the caudal SMA plays a central role in maintaining executive aspects of motor control that increases with approaching disease onset, compensating for dysfunctions in other executive parts of the motor system (e.g. the M1).
A brain's ability to compensate for the dysfunction and loss of neurons, occurring over a long period of time, results in late clinical manifestation of symptoms of AD and other dementias.
It is conceivable that increasing local damage limits the ability of SPL to effectively compensate for motor dysfunction in more advanced stages of symptomatic Huntington's disease.
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