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However, the fact that ANT is encoded in mammals by a multigene family means that the knockout of one isoform might entrain effects on the regulation of others, which can also compensate for any defect.
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In theory glucose oxidation can compensate for a defect in FAO.
It is worth noting that TLR4 can compensate for a defect in TLR2 during primary pneumococcal pneumonia [ 70].
Taken together, these results indicate that overexpression of activated CDC-42 can compensate for a defect in the CED-1/6/7 pathway and CED-10, but only in the presence of an active CED-2/5/12 CED-2/5/12
Consequently, proteins involved in membrane trafficking and in particular, lysosome biogenesis, may be upregulated to compensate for this defect.
However, the increased CoA affinity appears to be insufficient to compensate for the defect in the ATP binding.
Together, these results suggest that the etfdh mutation in xav results in metabolic reprogramming, which is not restricted to and cannot fully compensate for the defect in the fatty acid oxidation.
If a specific mutation has no effect on virulence, the finding does not necessarily mean that the disrupted target plays no role in virulence since an alternative pathway can compensate for the defect.
To compensate for this defect, other types of Medpor have been introduced.
Together, these data indicate that increased intracellular stores cannot fully compensate for the defect in release efficiency during intense stimulation.
The hyperinsulinemia associated with obesity helps normalize EGP and lipolytic rate but is not adequate to compensate for the defect in insulin-mediated skeletal muscle glucose uptake.
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