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In our study we aimed at discovering the compendium of regulatory elements that facilitate σ-dependent transcription, i.e., σ-dependent regulome.
Despite the existing data on σ-dependent transcription in D. vulgaris Hildenborough, we still do not have a complete understanding of the role of the σ-dependent regulome (defined as the compendium of regulatory elements that facilitate σ-dependent transcription) in this bacterium.
The miRNA regulome (defined as the compendium of regulatory elements that either regulate miRNA expression or are regulated by miRNA activity) is a critical component of the biological networks that govern cellular and systemic phenotypes [ Gennarino et al., 2012; Liang and Landweber 2007; Volinia et al., 2010].
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If he does get a reaction when he tells people that he works for the agency that produces those soft-cover compendiums of regulatory gobbledygook, it is most often this: How can you bear to read that stuff?
Our goal is to create a compendium of short regulatory motifs (6 – 12 mers).
Based on genome-wide studies of epigenetic marks that typify active enhancers, we recently identified the compendium of distal regulatory elements that dictate transcriptional programs during myogenesis.
In this work, we compile a compendium of putative regulatory upstream elements by using sequence and functional genomics data (see website [ 2]).
We finish the results section relating the AS signals identified to a compendium of known regulatory features we compiled, briefly reviewing some of the mechanistic insights suggested by our analysis before concluding with a discussion of related work and future directions.
This study introduces BEEM as a powerful tool for decoding regulatory programs from a compendium of gene expression profiles.
CLR algorithm is based on relevance network theory, infers cellular regulatory interactions from a compendium of expression profiles (the algorithm is available at http://m3d.mssm.edu/network_inference.html).html
The price of regulatory reform?
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com