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With the increasing knowledge on RA pathophysiology and genomewide studies demonstrating that loci related with TNF signaling pathways such as the NF-kB signaling pathway (TRAF1/C5, TNFAIP3, and REL) and other pathological processes such as enhanced citrullination (PADI4) may increase RA risk, it is compelling to explore how those loci could also influence the anti-TNF response [ 21– 28].
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Thus, there is a compelling need to explore novel therapeutic interventions for this disease.
Human infants provide a compelling opportunity to explore the hypothesis that the mirror neuron system plays a functional role in action understanding.
The co-distribution of the two families was not perfect, as shown Figure 2B, but it was compelling enough to explore further.
These observations provide compelling justification to explore myostatin inhibition gene therapy in animal models and, more recently, in BMD patients (Mendell et al., 2015; Rodino-Klapac et al., 2009).
Finally, evolutionary aspects related to the uniquely different diazotrophic behavior of the genus Trichodesmium and to its placement in the evolution of affiliated cyanobacteria with unusual diazotrophic behavior are yet other compelling research areas to explore.
Both are joined by Shackleton, whose singular live performances continue to explore compelling and unpredictable ground.
They had come to throw themselves at these peaks for a variety of compelling reasons — among them to explore nature and, in this lonely vastness, to explore themselves and their limits.
With the ferocious summer heat just a hazy memory, late autumn is the perfect time to explore this compelling city's unexpected delights.
Junger proved himself a first-rate reporter with an uncanny gift for narrative, but a reporter needs a compelling subject and a world to explore.
"I wanted to explore some compelling topics in neuroscience that people could relate to," he says.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com