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In the case of MM.LaFleur, one of the most compelling signals at the seed stage was the rapid growth in internet traffic, reflecting consumer demand for their "Bento Box" product offering, Okike said.
In particular, the degree of parallelism in the direction of divergence for most of the traits investigated reveals compelling signals of adaptation-driven differentiation.
"The idea was to have the experts look through the literature and see which might be the most compelling signals, and which areas were emerging but warranted more research," Thayer explains.
For most complex traits, the absence of compelling signals from linkage studies conducted in families segregating multifactorial diseases imposes an upper bound to feasible effect sizes; even so, it is easy to show that a limited number of low-frequency susceptibility alleles of medium effect could go a long way to explaining missing heritability.
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There is, therefore, no compelling signal of periodicity limited to any particular frequency range for the inter-pulse interval data in this dataset.
Genome-wide association studies (GWAS) have revealed compelling genetic signals influencing obesity risk in adults.
However, with over 2.5 million single-nucleotide polymorphisms (SNPs) annotated on the canine genome, the potential for performing unbiased surveys for genetic loci underlying traits via genome-wide association study (GWAS) has become a practical tool for canine geneticists, leading to compelling association signals for traits with reduced genetic complexity [3] [9].
Association analysis of this enriched data set did not yield any compelling additional signals of association.
Having identified compelling genetic signals, the next step is the functional analyses of these to assess how the associated alleles modulate gene or protein function.
Although, many variants have yet to be tested in follow-up studies, these six loci currently represent compelling GWAS signals worthy of follow-up investigation (Bertram and Tanzi 2009).
Genotype and allele counts for these variants in our complete series are shown in Online Resource 3. We first focused on six variants highlighted by Bertram and Tanzi (2009) as the most compelling GWAS signals worthy of follow-up investigation.
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