Overall, studies of IDE variants provide evidence for association with LOAD that is difficult to dismiss as a set of false positives, but the association is not compelling because replication is inconsistent and the results of meta-analyses do not achieve significance [41].
The compelling and extensive replication of numerous convergent efficacy measures by independent investigators and confirmation of activity in humans continue to place Aβ immunotherapy in the forefront of potential new treatments for AD.
However, since the underlying evidence is less compelling than suggested, replications are crucially required.
That point has become clear in the last year as researchers have gained compelling evidence that viral replication still occurs, although slowly, even when tests show no detectable virus.
One of the most compelling evidence lines that replication is perturbed at CFS and that correct handling of perturbed forks is important for CFS stability is provided by the observation that genetic downregulation of ATR, the upstream S-phase checkpoint kinase [ 35, 36], dramatically and specifically, affects fragility of CFS, even in the absence of aphidicolin [ 37].
Although the overall statistical evidence is still in favour of it increasing the risk for schizophrenia (P = 0.0012), the support is not compelling, raising the need for further replication.
Although K627 in PB2 is not the only marker for virulence of influenza viruses there is compelling evidence that the E627K change favors the replication and increases the virulence of some avian influenza viruses in mammals [46].
Despite considerable experimental and theoretical effort, no compelling scenarios currently exist for the origin of replication and translation, the key processes that together comprise the core of biological systems and the apparent pre-requisite of biological evolution.
These results offer compelling evidence that our CReST implementation is an accurate replication of R&C's brokerage implementation.
The evidence for slipped-strand replication errors directing tract expansion is initially conceptually compelling.
These data, combined with the association of the WD_1027-WD_1028 IGR with the same genes shown to be flanking the ori region in C. crescentus and R. prowazekii, provides compelling evidence that this is most likely, the origin of replication.
