These studies provide a compelling focus for pathway directed, rather than traditional tumour-type specific interventions.
We build a new, compelling picture of pathway involvement by showing that associations exist with additional gene family-members, namely EGFR, NRG2, and NRG3.
These signals activate survival pathways, compelling mobilization and differentiation of precursor cells into those necessary to befit the requirements of the body during development and in response to cellular and tissue stress.
We provide here, for the first time, compelling evidence that PINK1 pathway mitigates neuronal loss and increases life expectancy in an animal model of HD.
Our data strongly support previous studies [ 6, 22], both of which provide compelling evidence for a pathway involving the 'head-first' insertion of model signal-anchor sequences followed by their subsequent inversion to achieve their native type II topology (N-terminus cytosolic).
The unusual neurocognitive profile of Williams syndrome makes it a compelling model of the pathways between genes and human cognition.
Our finding that a key inhibitory regulator of neuregulin-ErbB is up-regulated in the MIA model along with a down-regulation of MAPK signaling is therefore compelling, suggesting the same pathways are targeted by genetic and environmental perturbations relevant to neurodevelopmental conditions.
The Forest uses a pathway to tell compelling stories: of okapi, which Brookfield was the first to breed, and of life in the Congo, in central Africa, from the perspective of locals, researchers and wildlife park rangers.
There is compelling evidence that the Smad pathway is necessary for both heart development in vivo and cardiomyocyte differentation from pluripotent stem cells.
Because normal levels of BATF stop cell division, this pathway presents a compelling target for drug modification.
