The plethora of genetic mutations in epigenetic regulators in FL shown in this study therefore offers a compelling model disease to strategically test epigenetically-targeted therapies.
A pathological role of the oxysterol EBI2 pathway is particularly compelling in diseases involving an immune system dysregulation, or diseases involving EBV infection.
These transcriptional responses along with the synergistic antiproliferative effect demonstrated for SK-BR-3 cells are a compelling collection of disease relevant observations.
This prospect is especially compelling in degenerative diseases like liver fibrosis, as these conditions often develop slowly, and therapies may not be necessary for all subclasses of patients [ 5].
It has been argued that "from a clinical perspective, the most compelling definition of (the) disease (of osteoarthritis) is one that combines the pathology of disease with pain that occurs with joint use" (termed "symptomatic knee OA") [ 5].
Of course, disease-specific philanthropies are unlikely to support molecular evolution research, unless it has a specific and compelling connection to their disease of choice, which is certainly a possibility.
In a report in the 15 November issue of Science, researchers present compelling evidence that the disease, for some families at least, is in the genes.
Recent compelling data on the disease burden of rotavirus and the power of vaccines to prevent it in low-resource settings informed the WHO's June 2009 recommendation that rotavirus vaccination be included in every nation's immunizations program [22].
This short video provides a compelling overview of the disease and what can be done about it.
