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The phylogeny-based methods, including HTreeQA, can avoid this problem by only examining phylogeny trees constructed from compatible intervals.
HTreeQA: We compute compatible intervals by using integer linear programming and construct a tristate semi-perfect phylogeny tree for each compatible interval.
We generated compatible intervals on the basis of the four-gamete rule (Hudson and Kaplan 1985) for the five classical founder inbred strains of the CC using MDA genotypes (Wang et al. 2010; Yang et al. 2011).
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If a compatible interval is not a subinterval of another compatible interval, it is called a maximal compatible interval.
For a given interval, a perfect phylogeny exists if and only if the interval is a compatible interval.
An interval C u, v (M ) is a compatible interval if every pair of SNP markers in the interval pass the four-gamete test (Hudson and Kaplan 1985).
The corresponding P-value is used as the nominal (uncorrected) P-value of the association between the compatible interval and the phenotype.
This becomes clearer in Figure 3D, where the four white head spot mice having white head spot located on the same branch of the tristate semi-perfect phylogeny tree built on the compatible interval at the QTL.
One way is to position neighboring mRNA chains at intervals compatible with the size of the ribosome, so that the translating ribosome can occupy the space between them.
Bilamellar tarsal rotation surgery was associated with more overcorrection of the entropion but the estimate was imprecise with very wide confidence intervals compatible with no effect, or more overcorrection in the tarsal advance group (OR 2.57, 95% CI 0.28 to 23.25, 312 eyes, I² = 0%) (Analysis 1.2).
Pairs of contigs whose ratio of average coverage differed by no more than 2 1 and that had only one uniquely aligning interval compatible with end-to-end joining were joined.
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