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Signal transit compartments represent the activated kinases as a ratio of phosphorylated/total kinase (normalized to 1 at baseline).
Unlike compartmental PK models, where compartments represent the sum of kinetically similar tissues, whole-body PBPK models segregate compartments based on anatomical considerations.
These functional compartments represent the physical basis for the assembly and turnover of signalling complexes, which in turn can define specialized endosomal lysosomal signalling platforms.
These compartments represent the following organelles or their parts: the outer and inner layer of the cell membrane, the cytoplasm, the endoplasmic reticulum, the cytoplasmatic and lumenal face of the Golgi apparatus, the nucleus, the mitochondrion and the lysosome.
Similar(56)
The mathematical model contains three compartments representing the liver, blood plasma, and periphery.
Essentially, the gut is separated into two main compartments representing the lumen (unabsorbed drug) and enterocyte (absorbed drug).
The first of these compartments represents the GI tract, which is the organ affected directly by Crohn's disease.
The PBTK model comprised five compartments representing the stratum corneum, viable epidermis, blood, fat, and other tissues.
The DTK model consisted of five compartments representing the surface, stratum corneum, viable epidermis, blood, and storage tissues.
However, the compartment size has been reduced to subcellular dimensions, with the SBSP compartments representing the membranes or their regions, and extracellular and intracellular aqueous phases.
As a result, SBSP depicts a biosystem as a set of homogeneous, morphologically based compartments, representing the bilayer regions, and extracellular and intracellular aqueous compartments.
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CEO of Professional Science Editing for Scientists @ prosciediting.com