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Adherent and nonadherent compartments contributed to these effects, and patient serum was a necessary component.
Filming cells expressing GFP-Rab5 (supplementary Movie 2 online) provided clear evidence that Rab5-positive compartments contributed to the accumulating swollen vesicle phenotype.
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Thus, it is likely that multiple compartments contribute to IFN type-I pathway activation that we measured in TSA tumours after treatment with 8GyX3 (Fig. 1c).
In summary, our study indicates endosomes and/or synaptic structures as the main compartments of active γ-secretase in brain, and that other subcellular compartments contribute to a minor degree.
Last, does subcellular trafficking of EGFR to different compartments contribute to their different roles?
All lung compartments contribute to the innate and the adaptive immune response.
Moreover, as described above, multiple cellular organelles and compartments contribute to glycerolipid metabolism.
In plants, several compartments contribute to the formation of ROS, including the plasma membrane, peroxisomes, chloroplasts and mitochondria.
Moreover, homeostasis and the buffering capacity of intracellular aqueous compartments contribute to the stability of proton and counterion concentrations.
While multiple compartments contribute to lipid synthesis in yeast (Zinser et al. 1991; Natter et al. 2005), most reactions are confined to single membrane compartments.
This approach could provide a means to address the important question whether dysfunctional translation at pre- and postsynaptic compartments contributes to neurodegenerative and neurodevelopmental diseases in vivo.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com