These cells then proliferate and differentiate in separate but adjacent compartments and function cooperatively to promote bone growth through the process of endochondral ossification.
In the receptor-mediated, clathrin-dependent endocytic pathway, Rab5, Rab7 and Rab11 are localized on distinct endosomal compartments, and function as marker proteins for early endosomes, late endosomes and recycling endosomes, respectively [18] [21].
Rab GTPases represent a family of more than 60 human proteins that mark distinct membrane-bound compartments and function in transport vesicle formation, motility, docking, and fusion (Stenmark, 2009; Hutagalung and Novick, 2011).
These two groups of genes were separately analyzed and were mapped to cellular compartments and biological functions (Table S1).
GO Biological Processes, Cellular Compartments and Molecular Functions were returned for 592 genes using the Homo sapiens GO database [32].
Functional Gene Ontology (GO) annotation of genes underlying these clusters revealed information about the biological processes, cellular compartments and molecular functions during C-VSMC development and osteoblast differentiation.
Differentially expressed probes within each of the groups identified by k-means clustering for C-VSMCs and osteoblasts were analyzed using DAVID Bioinformatics Resources 6.7 (http://david.abcc.ncifcrf.gov/) [ 51] to obtain a comprehensive description of the over-represented biological processes, cellular compartments and molecular functions.
To investigate rates and range of pelvic floor dysfunction complaints, including anterior and posterior compartments and sexual function, in an unselected population of primiparous women one year from delivery, and examine the degree of bother they cause.
These changes in intracellular localization, tissue compartments, and channel function, uniquely associated with malignant transformation, may offer a unique target for cancer therapy, likely able to spare normal cells.
