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However, in critically ill patients, intestinal epithelium disruption by shock or other insults may compromise this compartmentalized response and cause systemic bacteria and cell-wall translocation.
However, we contend that CARS should be considered an adapted compartmentalized response with the aim of silencing some acute pro-inflammatory genes and maintaining the expression of certain genes involved in the anti-infectious process.
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We previously reported data that suggest a compartmentalized host response in pneumococcal meningitis [ 33].
As reported elsewhere for extrapulmonary tuberculosis, including TBM [ 18], pleural [ 19], and pericardial tuberculosis [ 20], a highly compartmentalized inflammatory response in CSF was seen in patients with TBM.
However, this is unlikely, because focal infections such as meningitis or pneumonia are characterized by a highly compartmentalized immune response [ 15, 24].
Consistent with the combined TBM group, a highly compartmentalized inflammatory response was seen in both subgroups when the TBM group was divided into those who did and those who did not subsequently develop TBM-IRIS.
Anatomically compartmentalized immune responses are observed in DNA prime-rAd boost immunization [21], so we explored this for single-dose rAd immunization.
Taken together, these data indicate that PRO 2000 predominantly enhances compartmentalized mucosal IgA responses in mice.
Consistent with previously reported data[10], HCV-specific responses were compartmentalized to the liver and stronger than peripheral HCV-specific responses (Figure 3c).
The response to VAP might vary from compartmentalized forms that account for a local response with minor systemic compromise, whereas systemic spillover or escape of inflammation led to septic shock and bacteremia.
The color composition of ectopic eyespots induced on wings of butterflies from concerted selection lines (Fig. 4) further suggest that the threshold response is not compartmentalized across comparable regions of a wing surface (spanning at least three wing cells) where there is clear compartmentalization of focal signaling [ 67, 68].
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