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Thioredoxin levels are much less than GSH, however, TRX and GSH may have overlapping as well as compartmentalized functions in the activation and regulation of transcription factors (Valko et al 2006).
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Nevertheless, our observations are possibly consistent with a spatially compartmentalized function for the protein in vivo.
Careful overview of the hierarchy and in-depth examination of the modules in domain bigram networks shall shed lights on how cells compartmentalize their functions at various levels of granularity and how these functions collaborate and interact locally and globally.
A deeper understanding of PTEN's compartmentalized-functions will guide the rational design of novel therapies.
Although there are no substructures separated by membranes, the nucleus is compartmentalized for different functions in nucleic acid metabolism (1).
First, it is possible mechanisms exist within the cell or tissue to compartmentalize GEF function as the spatial expression patterns of all GEFs in the developing ventral nerve cord seems to be fairly broad.
We propose that different classes of EPFL genes regulate different aspects of ER family function and introduce a TMM-based discriminatory mechanism that permits simultaneous, yet compartmentalized and distinct, function of the ER family receptors in growth and epidermal patterning.
Decreased immune function is not compartmentalized; reduced immune cell function (and in some cases cell numbers) has been observed in both the myeloid and lymphoid lineages [ 23- 25].
A previous study showed that PLCD1 could be compartmentalized as a function of cell cycle progression [ 40].
It has become evident that sphingolipids are compartmentalized according to their functions, and that subcellular transport aids this sorting.
"As we move from rural to urban…houses become more isolated from the outside environment and also become more internally compartmentalized according to the function of the spaces," said coauthor Humberto Cavallin, a professor at the University of Puerto Rico's School of Architecture, at the press briefing.
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