However, current protein-protein interaction databases use agglomerated data, which conceptualize the weight as the probability of the actual interaction and average the important effects of simultaneous expression, intracellular compartmentalization, post-translational modifica tions and so on.
In other words, the functional activity of a protein depends on several factors such as interaction with other proteins, phosphorylation/dephosphorylation, subcellular compartmentalization, and other post-translational modifications.
"There was classic compartmentalization taking place," one of the officials said, adding, "This guy doesn't know who was doing the operation".
Karampinos et al. [ 19] showed that fat compartmentalization is significantly different between post-menopausal women with and without Type 2 diabetes.
These results suggest that nuclear compartmentalization may be associated with post-natal GKRP co-expression, a condition that has not been analysed in hypothalamic tanycytes or liver cells.
There are numerous mechanisms, processes and structures that affect gene regulation, such as methylation, chromatin structure, regulatory elements, transcription factors, polyadenylation, post-translational modifications and compartmentalization of proteins, and others (for review see [9]).
There are various in vivo mechanism such as red cell sequestering of post-hepatic products or compartmentalization of bioactive compounds in certain tissues and/or organs which could make such compounds unavailable for use in inflammatory situations.
The cell-autonomous effects of PRH and the non-cell-autonomous effects coupled with the ability of signalling pathways to control PRH expression, post-translational modification, subcellular compartmentalization or activity through altering the levels of PRH-interacting partners, affords almost limitless possibilities in the outcomes in development.
The synthesis of NO by nitric oxide synthases (NOS) is controlled by complex intrinsic and extrinsic factors such as post translational modification, co-factor and substrate compartmentalization, phosphorylation and specific interactions with other proteins such as calmodulins [ 41, 42].
An intelligence community hobbled, as the Post shows, by a toxic mixture of secrecy, compartmentalization, turf rivalry, and tremendous duplication of effort is further bedevilled by a problem familiar to every computer addict: too much information.
Similar compartmentalization of the T-cell response was observed at 10 months post-immunization.
