It is not clear to what extent this observation can be extrapolated to other model species: in mammalian genomes, there appears to be no corresponding compartmentalization of tissue-specific genes into co-regulated regions [ 6].
Lipids are major components of biological membranes, which maintain the integrity of cells and allow the compartmentalization of the cytoplasm into specific organelles.
This specific compartmentalization of Fyn to the NMDAR complex via RACK1 has broad implications for the actions of alcohol on the channel.
T2C employs a selective enrichment of the 3C ligation products in preselected regions of interest in order to identify their interactions within a domain as well as the compartmentalization of one or several specific regions of the genome.
This latter point is hardly surprising as TEPITOPE's predictions are based solely on binding to MHC II and do not attempt to model cellular compartmentalization of the antigen and specific proteolysis of the protein.
The contrast between in vivo-and in vitro-binding specificity suggests an intrinsic molecular mechanism or the involvement of other proteins for the specific compartmentalization of DLCs and their pro-apoptotic cargoes.
