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Experiments in hippocampal neurons illustrate that the distribution of older and younger mitochondrial protein within the cell is determined by subcellular spatial organization and compartmentalization of mitochondria into neurites and soma.
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However, these values do not take into consideration the compartmentalization of citrate into mitochondria and cytosol.
Gene transfer may be constrained for the same reasons as in the case of mitochondria: if compartmentalization of function (and thus the presence of the symbiont) is important, the major constraining factor for transfer is the ease of importability of proteins (targeting, import and assembly) into the compartment [ 1, 13].
One of the most interesting things that struck me in the 20 years that I have been studying the cell biology of mitochondria is the compartmentalization of both the organelle and the field.
Compartmentalization of this pathway into the mitochondria enabled high-level production of branched-chain alcohols.
Owing to the length and compartmentalization of neuronal processes, the localization and trafficking of mitochondria is crucial to maintain function.
The pathway model also incorporates mitochondrial compartmentalization and reversible trans-mitochondrial membrane reactions to more accurately describe the role of mitochondria in cancer cell proliferation.
The compartmentalization of central carbon metabolism in anaerobic conditions is evident from the vital anabolic role of mitochondria in the absence of oxygen [ 75].
The biosynthetic de novo pathway occurs in six steps, with cellular compartmentalization of specific steps in the cytosol or mitochondria.
Eukaryotic cells contain small structures called mitochondria; each of our muscle cells contains hundreds of mitochondria.
Eukaryotic compartmentalization within mitochondria and peroxisomes and substrate tunneling within multi-enzyme complexes have been well recognized.
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