Sentence examples for compartmentalization of lipin from inspiring English sources

The expression and compartmentalization of lipin may also be important for the regulation of VLDL formation.

In yeast, the homolog of lipin (Pah1p/Smp2p) associates with the promoter region of genes involved in phospholipid biosynthesis and regulates the expression of these genes [26].

34 The PAP catalytic motif is present in the carboxyl-terminal lipin domain (C-LIP) of lipin proteins.

42 This evolutionary conservation of lipin proteins indicates the important role of lipin proteins in cellular function.

Seipin knockdown increases levels of the lipin 1 substrate PA and decreases the association of lipin 1 with the ER membrane in differentiating adipocytes [ 17].

Acute adenoviral-mediated knockdown of lipin 1 or lipin 2 was shown to reduce hepatic DAG, PKC ε activation, and associated insulin resistance [ 37, 38].

Similarly, little is known about the expression of lipin and DGAT in cancer patients.

Of note, the strong activating effect of TSC22D4 knockdown on LIPIN gene expression is consistent with the reported functional role of LIPIN as a cytosolic phosphatidic acid phosphatase promoting hepatic lipogenesis, hepatic VLDL secretion, and hepatic insulin resistance.

Glucose and amino acid deprivation, which inhibits mTORC1 activity, promoted nuclear accumulation of lipin 1 and thus suppressed SREBP signaling.

Another potential mechanistic model is the plausible reduction in TAG synthesis through interaction and modulation of lipin 1, a PA phosphatase, by the C-terminus of seipin [ 66].

They revealed a significant batch effect in expression of lipin 1 (LPIN1), Chemokine (C-X-C motif) ligand 14 (CXCL14), serine dehydratase (SDS) and hepcidin antimicrobial peptide (HAMP).