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To the best of our knowledge, this is the first computational model of sphingolipid metabolism that includes compartmentalization based on the typical structure of a nondifferentiated eukaryotic cell.
Considering the airways as a collection and filtering system designed to condition air for use by the human body allows for discrete compartmentalization based on function.
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Knowledge is based on forgetting.
In the heat-treated conidia (Fig. 1C and D) two different patterns were observed: the conidia were either unstained showing clear cytoplasm or the dye was homogeneously distributed throughout the conidial cytoplasm without any evidence of compartmentalization. Based on these observations, the conidia were scored as viable only when they were able to compartmentalize the dye.
The model, which incorporates key transport and metabolic processes and subcellular compartmentalization, is based on dynamic mass balances of 30 chemical species in both capillary blood and tissue cells (cytosol and mitochondria) domains.
The model is based on the compartmentalization of the STR into zones and the use of simplified less computationally intensive gas/liquid flow simulations.
The epidemic transmission dynamics is based on an ILI compartmentalization as described in the subsection Models calibration (full details on the detailed formulation of the model are provided in the Additional File 1).
This is based on (a) the compartmentalization of the process of lipid peroxidation for the generation of organ failures coming from one cohort of patients with severe sepsis [ 7]; and (b) different clinical characteristics of severe sepsis elicited by MDR bacteria from those by susceptible bacteria [ 11].
Control of biochemical reactions in living cells is based on the principle of compartmentalization, whereby the access of substrates to the active sites of enzymes is regulated by the structure of organelles with semi-permeable membranes.
Divergence of preserved duplicates has the potential to lead to differential gene expression based on tissue or cellular compartmentalization (Innan and Kondrashov 2010).
A working model of the subcellular compartmentalization of scytonemin biosynthesis in the cell, based on the above genomic analyses, is provided in Figure 4. Following a UVA radiation cue, the redundant genomic copies of the trp and tyr genes are expressed to lead the production of the tryptophan and p-hydroxyphenylpyruvate monomers from chorismate.
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