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The time-series alveolar breath concentrations measured following active smoking showed that the post-exposure alveolar CO concentrations decreased slowly even in the early phase of the decay curves, indicating a mono-compartment uptake and elimination model for the human body.
When C-cholesteryl oleate-labeled HDL was placed into either the apical or the basolateral compartment, cellular uptake and internalization of the labeled cholesteryl ester was also observed from both compartments, but the uptake was significantly higher from the basolateral than from the apical surface of EC.
In the visceral compartment, pronounced uptake in the cricopharyngeus and posterior cricoarytenoid muscles on phonation can interfere with the interpretation of PET scans in patients with hypopharyngeal, oesophageal and thyroid cancers, in whom this physiological uptake may mimic pathology [2, 4, 6, 27].
Exchange reactions were added to allow the blood compartment to uptake and secrete metabolites into the extra-system.
In contrast, ColiGS contains additionally a periplasm compartment, hence, uptake of an exchange metabolite M involves 4 exchange reactions and 4 species (Menvironment ➔ Mextracellular space ➔ Mperiplasm ➔ Mcytoplasm).
For time-dependent BTA, the results were also expressed as the percentage of the initial drug concentration of the donor compartment for uptake (A B) and efflux (B A) over 48 h.
In order to show if InsP6 associated iron is completely compartmented after uptake or if iron is also released into the cytoplasm, expression of the iron responsive protein ferritin was analysed.
The accumulated activity in the under- and overlying tissue of the high uptake compartment was added to the low uptake compartment.
Most of the accumulated activity in the whole body, 63 ± 11%% (23 90 %), was deposited in the high uptake compartment and 37 ± 11%% (10 77 %) in the low uptake compartment.
The low uptake compartment corresponds to the remainder of the body.
The weight of the high uptake compartment was determined by assuming a density of unity and calculating the volume from the abdominal thickness and the area of the high uptake compartment.
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