The data are plotted as frequency ratios (f slope / f seq : where f seq is the actual base frequency tabulated from all bases comprising the sequences in the real sequence compartment) plotted versus the overall real (G+C)% of each individual DNA sequence compartment studied.
Already now, methods to conduct multi-compartment studies including equilibrium sampling measurements are available [14, 22, 23, 36].
The results of this study provide evidence that DHET does have significant effects on neuronal functioning in the motor compartments studied at the behavioral as well as the histochemical level for DBA/2 male mice.
In addition, DA rats expressed significantly higher levels of the pro-inflammatory cytokine Tnfα compared to PVG in all the anatomical compartments studied, however this was also found not to be protective against HSE.
These discrepancies may result from a disparity in the markers used to identify Tregs, the compartments studied (i.e. peripheral blood vs lymphoid tissues) and the stage of the disease.
To investigate the contribution of Tlr-pathway to the activation of innate immune cells in HSE, we assessed the change in mRNA expression of key molecules within this pathway (Figure 5K) after infection using qRT-PCR in the same compartments studied as with immunohistochemistry, i.e. the whiskers area, the trigeminal ganglia and the brain stem of susceptible DA and resistant PVG rats (Figure 1A).
Overall, as with Mcm-2, in normal larynx and laryngeal dysplasia there was a highly significant difference in Ki67 LI values between the four epithelial compartments studied (P<0.0001).
Moreover, because of the lack of numerous samples, it was not possible in this transcriptomic analysis to establish correlation between the different compartments studied, namely, serum, PBMC, and liver.
Although the present study did not attempt to investigate the effect of oestrous cycle stage on receptor staining, it was noted that the mare in oestrus showed the strongest staining intensity and highest proportion of stained cells for ERα in all of the uterine compartments studied.
These data are could be related to the differences in tissue compartments studied (blood versus lung), the use of a transgenic TGF-β1 modeling system in the mouse, and/or unaccounted for clinical factors in the patients such as age and comorbidities.
Recently, we published data showing that gluten intake in BALB/c mice led to a decreased proportion of γδ T cells in all lymphoid compartments studied, while the number of Th17 cells, which are associated with the development of autoimmunity, increased substantially in PLN [ 81].
