This finding is consistent with tumor initiation in a progenitor compartment and resistance of terminally differentiated AT2 cells to transformation although stochastic transgene shutdown cannot be excluded.
As the concentrations of the antimicrobials in the 5 smaller compartments are adjusted in accordance with breakpoints, growth on these compartments indicates resistance of the pathogen in question and hence a potential risk of treatment failure.
In agreement with the processing of PMP22 through the Golgi compartment and the resistance of the protein to Endo H at steady-state (Pareek et al., 1997), some anti-HA positive structures in both WT and C85S-PMP22 co-localize with VVL.
They also endorse the concept that failure of GLUT4 sorting to a perinuclearly-located, Stx6-positive sub-compartment causes insulin resistance.
Furthermore, the effects of solution velocity, compartment width, and membrane resistance on the power generation capability were investigated.
In the case of a braced frame in which each storey comprises a separate fire compartment with sufficient fire resistance, Eurocode 3 suggests that the buckling length may be taken as lfi= 0.5L in an intermediate storey and as lfi= 0.7L in the top storey, where L is the system length in the relevant storey.
Together these findings suggest that motile cilia are indeed electrically coupled to the cellular compartment via a high resistance cable determined by the length and cross-sectional area of a motile cilium (estimated as ~350 MΩ for an ideally insulated cable; Figure 2H, see Materials and methods).
Each compartment is made of resistances, capacitances, and inductances.
To ensure a fast dialysis of the intracellular compartment, only pipettes with resistances between 0.8 and 1.2 MΩ were used.
In order to characterise a model that would take into account the development of adaptive resistance, two compartments were defined: one for drug-susceptible, growing bacteria, and the other for insusceptible, resting bacteria.
