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In these cells, the PC-I trafficking pattern has been characterized extensively in previous studies: PC-I arrives at the cis-Golgi from the IC in 2 3 min and later progresses to the TGN by compartment progression in 12 15 min (Bonfanti et al., 1998; Mironov et al., 2001).
Again, this is compatible with compartment progression, and is in agreement with the immuno-EM data.
In this study, we only used conditions under which VSVG crosses the Golgi by compartment progression.
For instance, PC-I forms aggregates in the early Golgi (or earlier) and is efficiently transported in this condensed state by compartment progression.
This fast diffusion-based transport coexists in the same Golgi stacks with the slower movement of supramolecular cargo such as PC by compartment progression.
First, this measurement focuses on the medial joint but approximately 20% of patients with knee OA sustain lateral compartment progression that leads to pseudowidening of the medial joint.
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Thus, individuals enter this compartment through progression from early active disease or relapse/failure after ineffective treatment.
Other degenerative signs such as the impingement compartment or progression of the chondral damage were not developed over the 2 year follow-up period.
Taken together, these data suggest that blt/ blt mice have decreased efficiency of entry into the mature SP compartment and progression through the final maturation stages within the mature SP thymocyte population.
A mutation within a cell of cancer lineage may reduce or amplify the copy number of a specific gene or regulatory element without a direct effect on tumor cell fitness in the original anatomical compartment or progression stage.
The incremental increase in DEC1 expression in both the nuclear and cytoplasmic neoplastic cell compartments during progression of normal to in situ and invasive carcinoma suggests that DEC1 plays a role in breast cancer progression.
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