Here, the key interactor can be a ligand, an inhibitor, a protein, DNA, RNA, or another biomolecule, whereas the biological surroundings are often lysates of (cultured) cells, but also tissues, subcellular compartments, organs, and insects have been studied this way.
First, it should be remembered that, since introduced by Riley and Cournand [ 4] more than 50 years ago, physiological dead space is a virtual concept wherein the lung is conceived as a two-compartment organ in which one compartment is normal and the other is completely unperfused.
Using the brain as a model multi-compartment organ, Sun et al. report in an article in G3 that inter-strain variation in gene expression is greater in discrete brain regions compared to inter-strain transcriptional differences detected comparing whole brains (Sun et al. 2012).
The high uptake compartment includes organs with physiologically or pathologically high somatostatin receptor expression, such as the liver, spleen, kidneys and tumours.
The tissue specificity of the transgene expression was verified by immunohistochemical analysis of the HER2 and luciferase expression pattern in mammary glands of Δ16HER2-LUC transgenic females (F2 generation) and also in other tissues, including brain, salivary glands, lymphoid compartment, reproductive organs, kidney, heart, lung, liver, stomach, intestine (Table 1).
The inflammatory response further causes a redistribution of micronutrients from the circulating compartment to organs involved in acute phase-related synthetic mechanisms [ 71].
The organ retention function is the solution of the model in each compartment; the organ doses are directly related to the integral of radioactivity of Zr in source organs over 50 years.
Defecatory dysfunction characterized by incomplete evacuation and digital manipulation was associated with worsening posterior compartment pelvic organ prolapse.
In 77 patients (33%), anterior compartment pelvic organ prolapse predominated; 46 patients (19%) demonstrated posterior compartment prolapse, whereas 26 patients (11%) had apical prolapse.
Most of the injected tracer (~75 %) localised outside the VOIs modeled in the phantoms used by OLINDA/EXM, suggesting a low concentration of tracer distributed in the large compartments and organs and considered as "remainder" by OLINDA/EXM.
